Raised in Dallas, Rose was a painting and sculpture major at the University of Colorado Boulder before graduating from Parsons School of Design in 1993; she worked under Christian Francis Roth and Richard Tyler before her debut. In 2001 she drew attention designing the outfits worn by Jenna and Barbara Bush at their father's presidential inauguration, then expanded into retail with Bergdorf Goodman and Neiman Marcus.
Her clientele has included Jessica Alba, Mindy Kaling, Mary-Kate and Ashley Olsen, Selma Blair and the Princess of Wales. Rose debuted her first bridal collection in fall 2006 and later partnered with The Dessy Group on an exclusive bridesmaid line.