The name comes from the nicknames of Marco Marchi (Jo) and a childhood friend (Liu). Within five years the brand had expanded into jewelry and watches, childrenswear, underwear, beachwear and homewear, adding its own shoe collection in 2008. Campaigns over the years have starred Kate Moss, Karlie Kloss and Joan Smalls.
As of 2022 the company ran 160 stores in Italy and around 200 more, mainly across Europe. In 2019 Liu Jo acquired Blufin — home of Blumarine and Blugirl — as part of the "Italian Excellence" grouping of high-end brands.