Born in Fort Worth, Texas, Miller earned a BFA in apparel design at the Rhode Island School of Design and studied draping for a year at L'École de la Chambre Syndicale de la Couture Parisienne. After interning with Clovis Ruffin and heading design at P.J. Walsh, she launched the Nicole Miller company in 1982 with company president Bud Konheim. Her first shop opened on Madison Avenue in 1986, and the line first broke through with a conversational-print men's tie collection.
Her style runs body-conscious and bold — cocktail dresses, wedding attire and neckties chief among them — and she made headlines in 1998 as the first American to present ahead of the French collections. A member of the Council of Fashion Designers of America, Miller has dressed Beyoncé, Angelina Jolie, Susan Sarandon and Eva Longoria, and divides her time between Tribeca and Sag Harbor.