Palmer, born in Texas in 1981, trained in Dallas and then at Central Saint Martins; Harding, born in England in 1984, studied there too, graduating from the MA under Louise Wilson alongside peers including Simone Rocha. Inspired by Harding's experience as an ANDAM finalist, the pair founded Palmer Harding using his prize winnings, initially working out of his childhood bedroom in Rickmansworth. Their first collection showed at London Fashion Week in 2012, with British Fashion Council NewGen support following.
Their shirts have found notable wearers — Theresa May in a 2016 John Lewis capsule, and Michelle Obama in 'The Super Shirt' in 2017, the year the duo won the British Fashion Council/Vogue Designer Fashion Fund. The brand is stocked by Harrods, Liberty, Neiman Marcus and Net-A-Porter.