Reinaud, a Paris-trained advertising professional, started the label after friends asked her to tailor their clothes through pregnancy; her first design was a pair of maternity jeans with a flexible fit. The brand's debut store opened on Kensington Church Street in 2002, later expanding to New York, Paris, Dubai and Delhi.
Kate Middleton's Jolene Knot Front Dress sold out within two hours of being photographed, and Seraphine has dressed Angelina Jolie, Kate Winslet and Christina Aguilera. It won the Queen's Award for Enterprise in 2015 and 2020, and was acquired by Next plc in July 2025.