The house opened in Boston in 1845 and later moved its headquarters to New York. Under Gerald Murphy — who took over as president in 1934 after years abroad among the Lost Generation at Cap d'Antibes — Mark Cross became a fixture of mid-century glamour. Murphy's friendship with Alfred Hitchcock produced the overnight case carried by Grace Kelly's character in the 1954 film Rear Window, one of cinema's earliest examples of product placement.
After the Murphy family sold the company, the name passed through a succession of owners until it was shut down in the late 1990s by then-owner Sara Lee. Neal J. Fox bought and relaunched the house in 2011, returning production to the same Italian factories that had made its goods more than forty years earlier.