The brand was founded in 1962 by former model Marie St John and her husband Robert Gray. Marie hand-knit simple skirts and tops for herself; when fellow models took notice, Robert showed the designs to retailer Bullock's, which ordered 84 dresses. The couple built the business from Irvine, California — Marie on design and production, Robert on sales — and a St. John knit became, as one consultant put it, "almost like a uniform, a status symbol."
Escada bought an 80% stake in 1990, funding the brand's own boutiques, and St. John went public in 1993. Faces of the house have included Gisele Bündchen, Angelina Jolie and Kate Winslet. Headquartered in Anaheim, California, it is now owned by Fosun International under its Lanvin Group, which took a majority stake in 2017.