The company grew from a small factory run by André Brantegem and his brother in Lede, East Flanders. Sons of a cobbler, they specialised in ladies' shoes sold to wholesalers; in 1962 André opened a retail outlet at the factory, and that became the Brantano chain.
Ownership changed hands over the years — Macintosh Retail Group took over in 2007, later selling the UK arm and, eventually, the brand on through FNG N.V. The chain went into administration in March 2017, and its stores closed in June 2017.