Breguet trained under Ferdinand Berthoud and Jean-Antoine Lépine before opening his workshop on the Quai de l'Horloge in Paris. His clients ran to Marie Antoinette and Louis XVI, and his inventions reshaped the craft: the first self-winding watch, the Perpétuelle, in 1780; the world's first wristwatch, the No. 2639 for Caroline Bonaparte, in 1810; and the famed Marie-Antoinette pocket watch, No. 160, which took 44 years to complete.
Owned by the English Brown family from 1870 to 1970, the brand changed hands through the quartz crisis, was acquired by Investcorp in 1987, and since 1999 has been a subsidiary of the Swiss Swatch Group, headquartered in L'Abbaye. In 2025 it marked its 250th anniversary with the Classique Souscription, which won the Aiguille d'Or at the Grand Prix d'Horlogerie de Genève.